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<table width="100%" summary="page for colon"><tr><td>colon</td><td align="right">R Documentation</td></tr></table>

<h2>Chemotherapy for Stage B/C colon cancer</h2>

<h3>Description</h3>

<p>These are data from one of the first successful trials of
adjuvant chemotherapy for colon cancer. Levamisole is a low-toxicity
compound previously used to treat worm infestations in animals; 5-FU
is a moderately toxic (as these things go) chemotherapy agent. There
are two records per person, one for recurrence and one for death</p>


<h3>Usage</h3>

<pre>colon</pre>


<h3>Format</h3>



<table summary="Rd table">
<tr>
 <td align="left">
id:</td><td align="left"> id</td>
</tr>
<tr>
 <td align="left">
study:</td><td align="left"> 1 for all patients</td>
</tr>
<tr>
 <td align="left">
rx:</td><td align="left"> Treatment - Obs(ervation), Lev(amisole), Lev(amisole)+5-FU</td>
</tr>
<tr>
 <td align="left">
sex:</td><td align="left">  1=male</td>
</tr>
<tr>
 <td align="left">
age:</td><td align="left"> in years</td>
</tr>
<tr>
 <td align="left">
obstruct:</td><td align="left"> obstruction of colon by tumour</td>
</tr>
<tr>
 <td align="left">
perfor:</td><td align="left"> perforation of colon</td>
</tr>
<tr>
 <td align="left">
adhere:</td><td align="left"> adherence to nearby organs</td>
</tr>
<tr>
 <td align="left">
nodes:</td><td align="left"> number of lymph nodes with detectable cancer</td>
</tr>
<tr>
 <td align="left">
time:</td><td align="left"> days until event or censoring</td>
</tr>
<tr>
 <td align="left">
status:</td><td align="left"> censoring status</td>
</tr>
<tr>
 <td align="left">
differ:</td><td align="left"> differentiation of tumour (1=well, 2=moderate, 3=poor)</td>
</tr>
<tr>
 <td align="left">
extent:</td><td align="left"> Extent of local spread (1=submucosa, 2=muscle, 3=serosa,
4=contiguous structures)</td>
</tr>
<tr>
 <td align="left">
surg:</td><td align="left"> time from surgery to registration (0=short, 1=long)</td>
</tr>
<tr>
 <td align="left">
node4:</td><td align="left"> more than 4 positive lymph nodes</td>
</tr>
<tr>
 <td align="left">
etype:</td><td align="left"> event type: 1=recurrence,2=death</td>
</tr>
<tr>
 <td align="left">
</td>
</tr>

</table>


<h3>Note</h3>

<p>The study is originally described in Laurie (1989). 
The main report is found in Moertel (1990).  This data set is closest
to that of the final report in Moertel (1991).
A version of the data with less follow-up time was used in the
paper by Lin (1994).
</p>


<h3>References</h3>


<p>JA Laurie, CG Moertel, TR Fleming, HS Wieand, JE Leigh, J Rubin,
GW McCormack, JB Gerstner, JE Krook and J Malliard.  Surgical
adjuvant therapy of large-bowel carcinoma: An evaluation of
levamisole and the combination of levamisole and fluorouracil:
The North Central Cancer Treatment Group and the Mayo Clinic.
J Clinical Oncology, 7:1447-1456, 1989.
</p>
<p>DY Lin.  Cox regression analysis of multivariate failure time data:
the marginal approach.  Statistics in Medicine, 13:2233-2247, 1994.
</p>
<p>CG Moertel, TR Fleming, JS MacDonald, 
DG Haller, JA Laurie, PJ Goodman, JS Ungerleider, 
WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard. 
Levamisole and fluorouracil for adjuvant therapy of 
resected colon carcinoma. New England J of Medicine, 332:352-358,
1990.
</p>
<p>CG Moertel,  TR Fleming,  JS MacDonald, DG Haller, JA Laurie, CM Tangen,
JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA
Maillard, Fluorouracil plus Levamisole as and effective adjuvant
therapy after resection of stage II colon carcinoma: a final report.
Annals of Internal Med, 122:321-326, 1991.
</p>


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